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Can HMGI-C be used as an aid with MDM2 and CDK4 to differentiate liposarcoma subtypes from their mimics?
[dedifferentiated liposarcoma]
Liposarcoma
represents
the
most
common
soft
tissue
tumors
in
adults
.
The
tumors
are
characterized
by
a
high
morphological
diversity
and
a
great
variation
in
biological
behavior
.
Atypical
lipomatous
tumors
represent
a
distinctive
subset
of
mesenchymal
neoplasms
featuring
mature
adipocytic
differentiation
.
Histologically
,
atypical
lipomatous
tumor
might
be
easily
confused
with
lipoma
.
Conversely
,
dedifferentiated
liposarcoma
may
be
confused
with
other
spindle
cell
/
pleomorphic
undifferentiated
tumors
.
A
group
of
liposarcomas
was
analyzed
by
investigating
the
MDM
2
,
CDK
4
,
and
HMGI-C
proteins
.
The
study
was
extended
to
a
group
of
lipomas
and
non-lipomatous
sarcomas
,
to
determine
whether
the
immunohistochemical
investigation
of
these
proteins
might
play
any
diagnostic
role
.
Our
data
suggest
that
ordinary
lipomas
may
form
a
molecular
genetic
and
morphological
continuum
with
atypical
lipomatous
tumor
.
At
one
end
of
the
spectrum
are
lipomas
characterized
by
HMGI-C
activation
and
at
the
other
end
are
atypical
lipomatous
tumors
with
overrepresentation
of
the
HMGI-C
,
CDK
4
,
or
MDM
2
proteins
.
These
findings
not
only
provide
insights
into
the
molecular
pathogenesis
of
lipomatous
tumors
,
but
also
indicate
that
the
immunohistochemical
analysis
of
HMGI-C
,
CDK
4
,
or
MDM
2
may
help
to
increase
diagnostic
accuracy
.
H
MGI-C
is
a
useful
adjunct
in
the
diagnosis
of
atypical
lipomatous
tumor
and
dedifferentiated
liposarcoma
and
differentiates
them
from
their
mimics
.
Therefore
,
in
our
experience
,
HMGI-C
expression
alone
is
of
rather
limited
value
in
the
differential
diagnosis
of
liposarcoma
subtypes
.
Diseases
Validation
Diseases presenting
"lipomas"
symptom
cowden syndrome
dedifferentiated liposarcoma
focal myositis
liposarcoma
pleomorphic liposarcoma
proteus syndrome
well-differentiated liposarcoma
This symptom has already been validated