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Retroperitoneal liposarcoma with leiomyosarcomatous differentiation.
[dedifferentiated liposarcoma]
We
herein
describe
a
60
-
year
-old
Japanese
man
with
a
giant
retroperitoneal
liposarcoma
undergoing
leiomyosarcomatous
differentiation
.
He
was
admitted
to
our
hospital
because
of
a
5
-
month
history
of
dysphagia
and
abdominal
distention
.
Abdominal
computed
tomography
showed
a
giant
tumor
that
occupied
the
entire
retroperitoneal
space
.
The
majority
of
the
mass
was
lipomatous
and
low
density
;
both
a
heterogenous
and
solid
mass
were
also
present
.
A
giant
retroperitoneal
liposarcoma
was
diagnosed
,
and
tumor
resection
was
performed
.
At
surgery
,
the
tumor
was
mostly
isolated
from
the
retroperitoneum
and
other
organs
.
Histopathologically
,
the
tumor
comprised
well-differentiated
and
dedifferentiated
liposarcoma
with
heterologous
differentiation
of
the
leiomyosarcomatous
components
,
which
is
a
rare
phenomenon
in
liposarcoma
.
The
patient
was
alive
3
years
after
the
first
treatment
,
although
he
has
had
3
local
recurrences
(
approximately
one
recurrence
yearly
)
and
has
been
treated
by
repeated
resection
and
radiotherapy
.
Diseases
Validation
Diseases presenting
"although he has had 3 local recurrences"
symptom
dedifferentiated liposarcoma
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