Rare Diseases Symptoms Automatic Extraction
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A random Abstract
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Our Team
Galleria mellonella larvae as an infection model for group A streptococcus.
[acute rheumatic fever]
Group
A
streptococcus
is
a
strict
human
pathogen
that
can
cause
a
wide
range
of
diseases
,
such
as
tonsillitis
,
impetigo
,
necrotizing
fasciitis
,
toxic
shock
,
and
acute
rheumatic
fever
.
Modeling
human
diseases
in
animals
is
complicated
,
and
rapid
,
simple
,
and
cost-effective
in
vivo
models
of
GAS
infection
are
clearly
lacking
.
Recently
,
the
use
of
non-mammalian
models
to
model
human
disease
is
starting
to
re
-attract
attention
.
Galleria
mellonella
larvae
,
also
known
as
wax
worms
,
have
been
investigated
for
modeling
a
number
of
bacterial
pathogens
,
and
have
been
shown
to
be
a
useful
model
to
study
pathogenesis
of
the
M
3
serotype
of
GAS
.
In
this
study
we
provide
further
evidence
of
the
validity
of
the
wax
worm
model
by
testing
different
GAS
M-
types
,
as
well
as
investigating
the
effect
of
bacterial
growth
phase
and
incubation
temperature
on
GAS
virulence
in
this
model
.
In
contrast
to
previous
studies
,
we
show
that
the
M-
protein
,
among
others
,
is
an
important
virulence
factor
that
can
be
effectively
modeled
in
the
wax
worm
.
We
also
highlight
the
need
for
a
more
in
-depth
investigation
of
the
effects
of
experimental
design
and
wax
worm
supply
before
we
can
properly
vindicate
the
wax
worm
model
for
studying
GAS
pathogenesis
.
Diseases
Validation
Diseases presenting
"fever"
symptom
22q11.2 deletion syndrome
acute rheumatic fever
alexander disease
allergic bronchopulmonary aspergillosis
canavan disease
carcinoma of the gallbladder
child syndrome
congenital toxoplasmosis
cushing syndrome
cystinuria
dracunculiasis
erdheim-chester disease
esophageal adenocarcinoma
esophageal carcinoma
familial mediterranean fever
focal myositis
hodgkin lymphoma, classical
lamellar ichthyosis
legionellosis
locked-in syndrome
malignant atrophic papulosis
neonatal adrenoleukodystrophy
neuralgic amyotrophy
oculocutaneous albinism
papillon-lefèvre syndrome
pyomyositis
pyruvate dehydrogenase deficiency
scrub typhus
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
typhoid
waldenström macroglobulinemia
wolf-hirschhorn syndrome
This symptom has already been validated