Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Penicillamine revisited: historic overview and review of the clinical uses and cutaneous adverse effects.
[cystinuria]
Penicillamine
is
a
well-known
heavy
metal
chelator
,
classically
used
in
the
treatment
of
Wilson
disease
,
rheumatoid
arthritis
,
and
cystinuria
.
From
a
dermatologic
standpoint
,
penicillamine
was
found
to
be
useful
in
the
treatment
of
systemic
sclerosis
.
The
successful
therapeutic
uses
of
penicillamine
have
been
hindered
by
its
numerous
adverse
effects
,
both
cutaneous
and
extra
-
cutaneous
.
It
is
a
unique
drug
since
it
provokes
a
diversity
of
dermatologic
manifestations
that
include
(
1
)
acute
hypersensitivity
reactions
,
(
2
)
dermopathies
characterized
by
elastic
fiber
abnormalities
including
elastosis
perforans
serpiginosa
and
pseudo-
pseudoxanthoma
elasticum
,
(
3
)
autoimmune
disorders
such
as
pemphigus
and
penicillamine-induced
lupus
erythematosus-like
syndrome
,
and
(
4
)
miscellaneous
dermatoses
that
result
from
undefined
mechanisms
.
These
cutaneous
adverse
effects
may
correlate
with
the
dosage
and
duration
of
penicillamine
therapy
as
well
as
the
disease
being
treated
.
Diseases
Validation
Diseases presenting
"and"
symptom
achondroplasia
adrenomyeloneuropathy
aniridia
carcinoma of the gallbladder
cutaneous mastocytosis
cystinuria
esophageal squamous cell carcinoma
harlequin ichthyosis
hodgkin lymphoma, classical
hydrocephalus with stenosis of the aqueduct of sylvius
kallmann syndrome
liposarcoma
locked-in syndrome
neonatal adrenoleukodystrophy
omenn syndrome
oral submucous fibrosis
pleomorphic liposarcoma
primary hyperoxaluria type 1
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
sneddon syndrome
triple a syndrome
trochlear dysplasia
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom