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Increased ischaemia-modified albumin is associated with inflammation in acute rheumatic fever.
[acute rheumatic fever]
Ischaemia-modified
albumin
,
a
novel
biochemical
marker
for
tissue
ischaemia
,
was
found
to
be
associated
with
oxidative
stress
.
The
purpose
of
this
study
was
to
assess
the
role
of
ischaemia-modified
albumin
in
the
diagnosis
of
acute
rheumatic
fever
and
also
to
evaluate
the
ischaemia-modified
albumin
levels
in
children
with
heart
valve
disease
.
The
study
groups
,
aged
5
-
18
years
,
consisted
of
128
individuals
-
40
with
acute
rheumatic
fever
,
35
with
congenital
heart
valve
disease
,
33
with
chronic
rheumatic
heart
disease
,
and
20
healthy
control
subjects
.
The
ischaemia-modified
albumin
,
erythrocyte
sedimentation
rate
,
and
C-
reactive
protein
levels
of
the
acute
rheumatic
fever
group
were
significantly
higher
than
those
in
the
chronic
rheumatic
heart
disease
,
congenital
heart
valve
disease
,
and
control
groups
,
separately
(
p
<
0
.
001
)
.
The
ischaemia-modified
albumin
levels
in
both
carditis
and
isolated
arthritis
subgroups
of
children
with
acute
rheumatic
fever
were
significantly
higher
than
in
the
control
group
(
p
<
0
.
001
,
p
<
0
.
01
,
respectively
)
.
However
,
there
was
no
statistically
significant
difference
between
the
chorea
subgroup
and
control
subjects
.
In
addition
,
significant
correlations
were
observed
between
ischaemia-modified
albumin
and
acute
phase
reactants
of
patients
with
acute
rheumatic
fever
(
p
<
0
.
001
for
both
erythrocyte
sedimentation
rate
and
C-
reactive
protein
)
.
The
ischaemia-modified
albumin
levels
of
chronic
rheumatic
heart
disease
,
congenital
heart
valve
disease
,
and
control
subjects
were
similar
.
The
increased
level
of
ischaemia-modified
albumin
in
children
with
acute
rheumatic
fever
seems
to
be
associated
with
inflammation
.
However
,
further
studies
are
needed
to
provide
stronger
evidence
.
Diseases
Validation
Diseases presenting
"inflammation"
symptom
acute rheumatic fever
child syndrome
inclusion body myositis
kindler syndrome
oral submucous fibrosis
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