Diffuse cutaneous mastocytosis with generalized bullae.

[cutaneous mastocytosis]

We report on a 9 -month -old female infant with multiple tense bullae and erosions covering the entire body , including the face , scalp , and trunk . The histopathological examination revealed sub-epidermal bullae with a dense dermal cellular infiltrate . The infiltrate was identified as a collection of mast cells using toluidine blue and Giemsa stains . The direct immunofluorscence was negative . A diagnosis of cutaneous diffuse mastocytosis with generalized bullae was made based on these clinical and histopathological findings . In cases with diffuse cutaneous mastocytosis with generalized bullae , systemic involvement is more frequent and more severe compared to other types of cutaneous mastocytosis . Some lethal outcomes have been reported . This is the first reported case of diffuse cutaneous mastocytosis in the Korean literature .

Diseases
Validation

Diseases presenting "first reported case" symptom

achondroplasia

acute rheumatic fever

alexander disease

allergic bronchopulmonary aspergillosis

aniridia

cutaneous mastocytosis

dedifferentiated liposarcoma

epidermolysis bullosa simplex

fabry disease

focal myositis

harlequin ichthyosis

heparin-induced thrombocytopenia

kabuki syndrome

malignant atrophic papulosis

megacystis-microcolon-intestinal hypoperistalsis syndrome

pleomorphic liposarcoma

primary hyperoxaluria type 1

thoracic outlet syndrome

waldenström macroglobulinemia

well-differentiated liposarcoma

werner syndrome

wolf-hirschhorn syndrome

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