Diffuse cutaneous mastocytosis with generalized bullae.

[cutaneous mastocytosis]

We report on a 9 -month -old female infant with multiple tense bullae and erosions covering the entire body , including the face , scalp , and trunk . The histopathological examination revealed sub-epidermal bullae with a dense dermal cellular infiltrate . The infiltrate was identified as a collection of mast cells using toluidine blue and Giemsa stains . The direct immunofluorscence was negative . A diagnosis of cutaneous diffuse mastocytosis with generalized bullae was made based on these clinical and histopathological findings . In cases with diffuse cutaneous mastocytosis with generalized bullae , systemic involvement is more frequent and more severe compared to other types of cutaneous mastocytosis . Some lethal outcomes have been reported . This is the first reported case of diffuse cutaneous mastocytosis in the Korean literature .