Rare Diseases Symptoms Automatic Extraction

Neonatal onset diffuse cutaneous mastocytosis: a case report and review of the literature.

[cutaneous mastocytosis]

Diffuse cutaneous mastocytosis is a rare variant of mast cell disease with widespread erythroderma, which is normally clinically apparent in early infancy. We report the case of a neonate who presented with diffuse erythrodermic rash and bullous lesions. Biopsy specimens showed a dense dermal infiltrate of mast cells. Serum histamine and tryptase levels were elevated. No somatic mutation of the c-kit gene was found. Blistering ceased at 5 months of age, but atopic dermatitis appeared at 6 months and allergic workup revealed a high level of food-specific IgE. Herein, we describe the case and provide the first review of the literature on neonatal onset diffuse cutaneous mastocytosis to clarify the prognosis of this condition.

Diseases presenting "atopic dermatitis" symptom

  • allergic bronchopulmonary aspergillosis
  • cutaneous mastocytosis
  • erythropoietic protoporphyria
  • harlequin ichthyosis
  • kallmann syndrome
  • lamellar ichthyosis
  • omenn syndrome
  • werner syndrome

This symptom has already been validated