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Neonatal onset diffuse cutaneous mastocytosis: a case report and review of the literature.
[cutaneous mastocytosis]
Diffuse
cutaneous
mastocytosis
is
a
rare
variant
of
mast
cell
disease
with
widespread
erythroderma
,
which
is
normally
clinically
apparent
in
early
infancy
.
We
report
the
case
of
a
neonate
who
presented
with
diffuse
erythrodermic
rash
and
bullous
lesions
.
Biopsy
specimens
showed
a
dense
dermal
infiltrate
of
mast
cells
.
Serum
histamine
and
tryptase
levels
were
elevated
.
No
somatic
mutation
of
the
c-kit
gene
was
found
.
Blistering
ceased
at
5
months
of
age
,
but
atopic
dermatitis
appeared
at
6
months
and
allergic
workup
revealed
a
high
level
of
food-
specific
IgE
.
Herein
,
we
describe
the
case
and
provide
the
first
review
of
the
literature
on
neonatal
onset
diffuse
cutaneous
mastocytosis
to
clarify
the
prognosis
of
this
condition
.
Diseases
Validation
Diseases presenting
"dense dermal"
symptom
cutaneous mastocytosis
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