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Oral and topical sodium cromoglicate in the treatment of diffuse cutaneous mastocytosis in an infant.
[cutaneous mastocytosis]
Diffuse
cutaneous
mastocytosis
(
DCM
)
is
a
rare
,
severe
,
variant
of
cutaneous
mastocytosis
.
The
authors
report
the
case
of
a
male
infant
who
developed
maculae
and
maculopapulae
on
his
legs
and
abdomen
when
aged
3
.
5
months
,
which
spread
to
all
body
surfaces
within
weeks
.
Diagnosis
of
DCM
was
made
at
the
age
of
6
months
when
he
had
developed
extensive
bullous
eruptions
,
generalised
pruritus
,
flushing
and
abdominal
pain
.
Treatment
was
started
with
oral
dimethindine
maleate
.
At
the
age
of
18
months
,
oral
sodium
cromoglicate
(
SCG
)
was
introduced
.
At
the
age
of
23
months
,
additional
treatment
was
started
with
a
cutaneous
emulsion
containing
4
%
SCG
.
Continued
treatment
with
oral
dimethindine
maleate
,
oral
SCG
with
the
dose
maintained
at
25
mg
/
kg
/
day
,
and
SCG
4
%
cutaneous
emulsion
applied
two
to
four
times
daily
has
resulted
in
a
steady
improvement
of
symptoms
and
skin
appearance
.
Diseases
Validation
Diseases presenting
"skin appearance"
symptom
cutaneous mastocytosis
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