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A random Abstract
Our Project
Our Team
Evaluation of the WHO criteria for the classification of patients with mastocytosis.
[cutaneous mastocytosis]
Diagnosis
and
classification
of
mastocytosis
is
currently
based
on
the
World
Health
Organization
(
WHO
)
criteria
.
Here
,
we
evaluate
the
utility
of
the
WHO
criteria
for
the
diagnosis
and
classification
of
a
large
series
of
mastocytosis
patients
(
n
=
133
)
,
and
propose
a
new
algorithm
that
could
be
routinely
applied
for
refined
diagnosis
and
classification
of
the
disease
.
Our
results
confirm
the
utility
of
the
WHO
criteria
and
provide
evidence
for
the
need
of
additional
information
for
(
1
)
a
more
precise
diagnosis
of
mastocytosis
,
(
2
)
specific
identification
of
new
forms
of
the
disease
,
(
3
)
the
differential
diagnosis
between
cutaneous
mastocytosis
vs
systemic
mastocytosis
,
and
(
4
)
improved
distinction
between
indolent
systemic
mastocytosis
and
aggressive
systemic
mastocytosis
.
Based
on
our
results
,
a
new
algorithm
is
proposed
for
a
better
diagnostic
definition
and
prognostic
classification
of
mastocytosis
,
as
confirmed
prospectively
in
an
independent
validation
series
of
117
mastocytosis
patients
.
Diseases
Validation
Diseases presenting
"as confirmed prospectively in an independent validation series of 117 mastocytosis patients"
symptom
cutaneous mastocytosis
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