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Gastroesophageal reflux disease accompanying urticaria pigmentosa.
[cutaneous mastocytosis]
A
few
case
reports
have
only
been
published
to
date
,
which
show
the
possible
link
between
mastocytosis
and
gastroesophageal
reflux
disease
(
GERD
)
.
Here
,
we
present
a
17
-
month
-old
boy
with
urticaria
pigmentosa
who
also
suffered
from
GERD
.
First
skin
lesions
accompanied
by
gastrointestinal
symptoms
(
regurgitations
,
appetite
worsening
)
were
noticed
at
the
age
of
four
months
.
At
that
time
,
they
were
misdiagnosed
as
symptoms
of
cow
's
milk
allergy
.
Despite
the
cow
's
milk-free
diet
,
the
skin
and
gastrointestinal
symptoms
slowly
worsened
and
the
patient
was
referred
to
us
for
further
diagnostics
several
months
later
.
Based
on
the
clinical
presentation
of
skin
lesions
,
presence
of
pruritus
and
positive
Darier
's
sign
,
cutaneous
mastocytosis
was
diagnosed
;
24
-
hour
pH-metry
revealed
an
increased
number
of
acidic
refluxes
and
biopsy
of
duodenal
mucosa
showed
numerous
mast
cells
.
Taking
into
account
these
findings
,
the
gastrointestinal
symptoms
were
supposed
to
be
a
manifestation
of
mastocytosis
.
Treatment
with
sodium
cromoglycate
,
cetirizine
,
ranitidine
and
probiotics
resulted
in
pruritus
alleviation
,
improvement
of
appetite
and
sleeping
as
well
as
increase
of
body
weight
.
Diseases
Validation
Diseases presenting
"gastrointestinal symptoms"
symptom
alpha-thalassemia
congenital toxoplasmosis
cutaneous mastocytosis
familial mediterranean fever
hirschsprung disease
junctional epidermolysis bullosa
kindler syndrome
malignant atrophic papulosis
systemic capillary leak syndrome
typhoid
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