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Acute phase protein levels in dogs with mast cell tumours and sarcomas.
[cutaneous mastocytosis]
The
acute
phase
proteins
(
APP
)
form
part
of
a
non-
specific
host
response
to
inflammation
.
They
may
be
induced
by
a
range
of
different
causes
,
including
infection
,
inflammation
,
cancer
and
trauma
.
As
they
form
part
of
the
earliest
response
to
such
insults
,
they
have
potential
for
early
identification
of
disease
.
In
people
,
APP
levels
have
been
shown
to
correlate
both
with
the
extent
of
disease
and
also
the
prognosis
in
several
forms
of
neoplasia
,
including
prostate
,
oesophageal
and
colorectal
cancer
.
As
such
,
they
can
be
used
as
prognostic
and
monitoring
tools
.
To
date
,
similar
studies
in
veterinary
patients
have
been
limited
,
largely
retrospective
in
nature
and
many
are
non-
specific
for
tumour
type
.
The
purpose
of
this
study
was
to
evaluate
a
panel
of
four
APPs
in
dogs
with
naturally
occurring
mast
cell
tumours
(
MCTs
)
and
sarcomas
to
identify
in
the
first
instance
whether
increased
levels
of
individual
APPs
,
or
identifiable
combinations
of
APPs
,
was
linked
with
the
presence
of
disease
.
In
the
patients
with
MCTs
,
C-
reactive
protein
(
CRP
)
and
α-
1
acid
glycoprotein
levels
increased
,
with
a
concurrent
drop
in
serum
amyloid
A
levels
.
In
the
sarcoma
patients
,
CRP
,
α-
1
acid
glycoprotein
and
haptoglobin
were
increased
.
These
findings
suggest
that
specific
solid
tumour
types
in
dogs
may
be
associated
with
specific
changes
in
APP
profiles
.
Diseases
Validation
Diseases presenting
"increased levels of"
symptom
canavan disease
cutaneous mastocytosis
gm1 gangliosidosis
harlequin ichthyosis
inclusion body myositis
krabbe disease
primary effusion lymphoma
von hippel-lindau disease
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