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Acute phase protein levels in dogs with mast cell tumours and sarcomas.
[cutaneous mastocytosis]
The
acute
phase
proteins
(
APP
)
form
part
of
a
non-
specific
host
response
to
inflammation
.
They
may
be
induced
by
a
range
of
different
causes
,
including
infection
,
inflammation
,
cancer
and
trauma
.
As
they
form
part
of
the
earliest
response
to
such
insults
,
they
have
potential
for
early
identification
of
disease
.
In
people
,
APP
levels
have
been
shown
to
correlate
both
with
the
extent
of
disease
and
also
the
prognosis
in
several
forms
of
neoplasia
,
including
prostate
,
oesophageal
and
colorectal
cancer
.
As
such
,
they
can
be
used
as
prognostic
and
monitoring
tools
.
To
date
,
similar
studies
in
veterinary
patients
have
been
limited
,
largely
retrospective
in
nature
and
many
are
non-
specific
for
tumour
type
.
The
purpose
of
this
study
was
to
evaluate
a
panel
of
four
APPs
in
dogs
with
naturally
occurring
mast
cell
tumours
(
MCTs
)
and
sarcomas
to
identify
in
the
first
instance
whether
increased
levels
of
individual
APPs
,
or
identifiable
combinations
of
APPs
,
was
linked
with
the
presence
of
disease
.
In
the
patients
with
MCTs
,
C-
reactive
protein
(
CRP
)
and
α-
1
acid
glycoprotein
levels
increased
,
with
a
concurrent
drop
in
serum
amyloid
A
levels
.
In
the
sarcoma
patients
,
CRP
,
α-
1
acid
glycoprotein
and
haptoglobin
were
increased
.
These
findings
suggest
that
specific
solid
tumour
types
in
dogs
may
be
associated
with
specific
changes
in
APP
profiles
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated