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[Bullous mastocytosis in infancy: a rare presentation].
[cutaneous mastocytosis]
Mastocytosis
is
a
rare
condition
related
to
an
abnormal
proliferation
of
mast
cells
and
their
accumulation
in
tissues
.
Cutaneous
mastocytosis
is
the
most
common
form
and
mainly
affects
newborns
and
infants
.
The
symptoms
are
caused
by
the
release
of
mediators
contained
in
mast
cells
,
including
histamine
.
Mastocytosis
may
be
associated
with
a
mutation
in
the
gene
encoding
the
c-kit
receptor
.
Clinically
,
there
are
different
dermatological
findings
,
which
combine
acute
cutaneous
,
digestive
,
or
even
hemodynamic
manifestations
in
varying
degrees
.
The
diagnosis
is
confirmed
by
the
histological
study
of
a
skin
sample
.
We
report
here
the
case
of
a
4
-
month
-old
infant
suffering
from
diffuse
cutaneous
bullous
mastocytosis
,
a
very
rare
variety
of
mastocytosis
.
This
infant
had
an
erosive
and
bullous
manifestation
of
dermatosis
,
initially
confused
with
impetigo
.
The
proliferation
of
bullous
lesions
led
to
her
hospitalization
.
Codeine
intake
for
pain
was
responsible
for
a
large
and
extensive
bullous
reaction
associated
with
anaphylactic
shock
.
This
context
of
bullous
spread
occurring
after
taking
codeine
led
to
the
suspicion
of
bullous
diffuse
cutaneous
mastocytosis
,
a
diagnosis
that
was
confirmed
histologically
.
This
observation
demonstrates
the
difficulty
of
mastocytosis
diagnosis
,
mostly
due
to
its
rarity
,
especially
in
its
diffuse
bullous
forms
.
The
rapid
deterioration
of
this
patient
,
after
the
codeine
prescription
,
emphasizes
the
importance
of
the
eviction
of
histamine-releaser
compounds
in
the
management
of
this
disease
.
Diseases
Validation
Diseases presenting
"a mutation in the gene encoding the c-kit receptor"
symptom
cutaneous mastocytosis
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