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Stem cell factor contributes to tumorigenesis of mast cells via an autocrine/paracrine mechanism.
[cutaneous mastocytosis]
Mastocytosis
is
a
disease
accompanied
by
the
abnormal
expansion
and
accumulation
of
mast
cells
.
Although
the
D
816
V
mutation
is
detected
in
most
cases
of
systemic
mastocytosis
,
the
mutation
is
rarely
observed
in
other
forms
of
mastocytosis
,
such
as
cutaneous
mastocytosis
and
mast
cell
leukemia
/
sarcoma
,
for
which
the
mechanism
of
tumorigenesis
remains
unknown
.
In
this
study
,
we
demonstrated
a
novel
mechanism
of
mast
cell
tumorigenesis
via
SCF
autocrine
/
paracrine
release
.
SCF
was
highly
expressed
in
a
WT
KIT
-expressing
HRMC
line
,
contributing
to
the
phosphorylation
of
KIT
.
Neutralization
of
external
SCF
using
a
neutralizing
antibody
or
suppression
of
SCF
production
by
RNA
interference
inhibited
the
growth
of
HRMC
cells
,
indicating
the
essential
role
of
SCF
in
cell
proliferation
.
To
the
best
of
our
knowledge
,
this
is
the
first
report
to
determine
the
significant
contribution
of
SCF
autoproduction
to
neoplastic
proliferation
of
mast
cells
.
These
results
indicate
the
possibility
that
targeting
SCF
production
may
become
a
novel
treatment
for
mast
cell
malignancies
.
Diseases
Validation
Diseases presenting
"mast cell leukemia"
symptom
cutaneous mastocytosis
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