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Expression of the basophil-specific antibodies 2D7 and BB1 in patients with cutaneous Mastocytosis.
[cutaneous mastocytosis]
2
D
7
and
BB
1
are
thought
to
be
basophil-
specific
markers
.
In
this
study
,
we
tested
both
antibodies
in
different
skin
and
mast
cell
disorders
with
the
aim
of
determining
whether
it
was
possible
to
differentiate
between
benign
and
aggressive
presentations
of
mastocytosis
.
Using
the
antibodies
2
D
7
,
BB
1
,
and
c-
Kit
,
we
performed
an
immunohistochemical
study
of
skin
biopsy
specimens
from
patients
with
cutaneous
mastocytosis
(
15
urticaria
pigmentosa
and
telangiectatic
macularis
eruptive
perstans
)
and
liver
or
bone
marrow
biopsy
specimens
from
patients
with
systemic
mastocytosis
.
A
basophil
leukemia
cell
line
was
used
as
a
reference
.
Peripheral
blood
basophils
from
healthy
donors
were
used
as
controls
.
We
observed
intense
expression
of
2
D
7
and
BB
1
in
all
skin
biopsy
specimens
from
patients
with
cutaneous
mastocytosis
.
Immunostaining
of
liver
and
bone
marrow
specimens
from
patients
with
systemic
mastocytosis
with
2
D
7
and
BB
1
antibodies
was
negative
.
Specimens
from
patients
with
either
type
of
mastocytosis
showed
similarly
strong
expression
of
c-
Kit
.
The
basophil
cell
line
showed
a
2
D
7
and
a
BB
1
profile
,
with
intense
expression
of
c-
Kit
.
Peripheral
blood
basophils
exhibited
notable
immunostaining
for
2
D
7
,
BB
1
,
and
c-
Kit
.
2
D
7
and
BB
1
are
expressed
in
cutaneous
mastocytosis
,
although
this
expression
is
lost
when
mast
cell
proliferation
is
systemic
,
thus
reflecting
either
a
different
cellular
differentiation
stage
or
the
presence
of
basophils
in
these
skin
diseases
.
Diseases
Validation
Diseases presenting
"bone marrow biopsy specimens"
symptom
cutaneous mastocytosis
waldenström macroglobulinemia
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