Rare Diseases Symptoms Automatic Extraction
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Determination of cortisol in serum, saliva and urine.
[cushing syndrome]
Cortisol
is
quantitatively
the
major
glucocorticoid
product
of
the
adrenal
cortex
.
The
main
reason
to
measure
cortisol
is
to
diagnose
human
diseases
characterised
by
deficiency
of
adrenal
steroid
excretion
in
Addison
's
disease
or
overproduction
in
Cushing
's
syndrome
(
CS
)
.
In
both
cases
a
sensitive
,
accurate
and
reproducible
assay
of
cortisol
is
required
.
Several
methods
have
been
described
for
the
quantitative
measurement
of
cortisol
in
both
serum
and
urine
.
The
most
widely
used
methods
in
routine
clinical
laboratories
are
immunoassays
(
IA
)
and
enzyme
immunoassays
(
EIA
)
,
luminescence
and
fluorescence
assays
,
which
are
available
in
numerous
commercial
kits
and
on
automated
platforms
.
However
,
there
remains
a
number
of
problems
in
the
so
-called
direct
immunoassays
if
extraction
and
prepurification
are
not
carried
out
before
the
assay
.
Recently
,
more
specific
chromatographic
methods
have
been
introduced
,
such
as
high
pressure
liquid
chromatographic
(
HPLC
)
or
liquid
chromatography
tandem
mass
spectrometric
assays
(
LC
-
MS
/
MS
)
.
The
high
specificity
especially
of
LC
-
MS
/
MS
facilitates
reliable
measurement
of
cortisol
both
in
plasma
,
urine
and
saliva
samples
.
Diseases
Validation
Diseases presenting
"high specificity"
symptom
adrenal incidentaloma
cushing syndrome
esophageal adenocarcinoma
esophageal squamous cell carcinoma
inclusion body myositis
krabbe disease
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