Subclinical Cushing syndrome: a review.

[cushing syndrome]

Owing to its diagnostic challenges , subclinical Cushing syndrome (SCS ) is likely to be highly underdiagnosed and undertreated , and the overall incidence may be as high as 5 % to 20 % in patients with adrenal incidentalomas . The diagnosis can be established by a systematic and thorough biochemical evaluation . SCS has been associated with significant morbidity , which at least partly may be reversed by surgery . Given the low rates of complications and the possibility to reverse the detrimental effects of elevated cortisol secretion , minimally invasive adrenalectomy is recommended for patients with biochemically proven or suspected SCS who are appropriate surgical candidates .