Hereditary gynaecological malignancies: advances in screening and treatment.

[cowden syndrome]

In the last two decades there have been significant advances in our understanding of female genital tract tumours . The discovery of BRCA 1 and BRCA 2 genes in ovarian cancer and the mismatch repair genes in endometrial carcinoma has revolutionized our approach to the diagnosis and screening of women for ovarian and uterine cancers . This review discusses the pathogenesis of these two hereditary syndromes in depth and explains how the molecular genetics is tailoring the manner in which these diseases are diagnosed and potentially treated . Other , less common hereditary conditions associated with gynaecological tract manifestations , such as Cowden syndrome , Peutz-Jeghers syndrome , Gorlin syndrome and hereditary leiomyomatosis and renal cell carcinoma , are also summarized briefly .