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A random Abstract
Our Project
Our Team
Otopathology in congenital toxoplasmosis.
[congenital toxoplasmosis]
To
describe
the
temporal
bone
histopathology
in
children
with
congenital
toxoplasmosis
.
Toxoplasmosis
is
a
parasitic
infection
caused
by
Toxoplasma
gondii
.
If
fetal
infection
occurs
early
in
gestation
,
severe
inflammation
and
necrosis
can
cause
brain
lesions
,
chorioretinitis
,
and
hearing
loss
.
Hearing
loss
in
congenital
toxoplasmosis
may
be
preventable
with
early
diagnosis
and
treatment
.
The
temporal
bones
of
9
subjects
with
congenital
toxoplasmosis
were
removed
at
autopsy
and
studied
under
light
microscopy
.
Cytocochleograms
were
constructed
for
hair
cells
,
the
stria
vascularis
,
and
cochlear
neuronal
cells
.
Three
(
33
%
)
of
9
subjects
were
found
to
have
parasites
in
the
temporal
bone
.
The
organism
was
identified
in
the
internal
auditory
canal
,
the
spiral
ligament
,
stria
vascularis
,
and
saccular
macula
.
The
cystic
form
of
the
parasite
was
not
associated
with
the
inflammatory
response
seen
in
the
active
tachyzoite
form
.
We
infer
that
the
hearing
loss
of
toxoplasmosis
is
likely
the
result
of
a
postnatal
inflammatory
response
to
the
tachyzoite
form
of
T
.
gondii
.
Our
findings
have
implications
for
the
early
identification
and
management
of
Toxoplasmosis
.
Diseases
Validation
Diseases presenting
"early identification"
symptom
22q11.2 deletion syndrome
allergic bronchopulmonary aspergillosis
congenital toxoplasmosis
cutaneous mastocytosis
esophageal carcinoma
kabuki syndrome
krabbe disease
phenylketonuria
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