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A potential association between Toxoplasma gondii infection and schizophrenia in mouse models.
[congenital toxoplasmosis]
Schizophrenia
is
a
serious
neuropsychiatric
disease
of
uncertain
etiology
,
which
causes
human
mental
disorder
and
affects
about
1
%
of
the
population
.
In
recently
years
,
some
studies
showed
that
some
cases
of
schizophrenia
may
be
associated
with
Toxoplasma
gondii
infection
.
In
order
to
investigate
a
potential
association
between
Toxoplasma
infection
and
schizophrenia
,
we
investigated
the
relative
clinical
symptom
of
schizophrenia
such
as
learning
and
memory
capability
,
depression
and
stereotypy
to
find
some
useful
information
by
behavioral
test
in
mouse
models
.
Our
results
demonstrated
that
mice
from
Toxoplasma
infection
and
MK
-
801
administration
(
as
the
model
of
schizophrenia
)
were
impaired
in
learning
and
memory
capability
,
and
they
had
more
serious
depression
and
stereotypy
compared
with
the
control
mice
,
especially
the
mice
from
congenital
Toxoplasma
infection
.
In
addition
,
our
results
clearly
showed
that
the
number
of
cysts
in
brain
tissue
of
congenital
Toxoplasma
infection
mice
was
significantly
low
than
in
acquired
Toxoplasma
infected
mice
.
Collectively
,
these
results
suggested
a
potential
association
between
Toxoplasma
infection
and
schizophrenia
.
