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Differential apoptosis in BeWo cells after infection with highly (RH) or moderately (ME49) virulent strains of Toxoplasma gondii is related to the cytokine profile secreted, the death receptor Fas expression and phosphorylated ERK1/2 expression.
[congenital toxoplasmosis]
Alterations
of
apoptosis
are
commonly
associated
with
pregnancy
complications
and
abortion
.
Modulation
of
apoptosis
is
a
relevant
feature
of
Toxoplasma
gondii
infection
and
it
is
related
to
parasite
strain
types
.
The
aim
of
the
present
study
was
to
evaluate
the
possible
factors
that
are
involved
in
the
differential
apoptosis
of
BeWo
cells
infected
with
distinct
T
.
gondii
strain
types
.
Human
trophoblastic
cells
(
BeWo
cell
line
)
were
infected
with
RH
or
ME
49
strains
,
the
cytokine
production
was
measured
and
the
phosphorylation
of
anti-apoptotic
ERK
1
/
2
protein
was
analyzed
.
Also
,
cells
were
treated
with
different
cytokines
,
infected
with
RH
or
ME
49
strain
,
and
analyzed
for
apoptosis
index
and
Fas
/
CD
9
5
death
receptor
expression
.
M
E
49
-
infected
BeWo
cells
exhibited
a
predominantly
pro-
inflammatory
cytokine
profile
,
whereas
cells
infected
with
RH
strain
had
a
higher
production
of
anti-
inflammatory
cytokines
.
Also
,
the
incidence
of
apoptosis
was
higher
in
ME
49
-
infected
cells
,
which
have
been
treated
with
pro-
inflammatory
cytokines
compared
to
cells
infected
with
RH
and
treated
with
anti-
inflammatory
cytokines
.
Moreover
,
Fas
/
CD
9
5
expression
was
higher
in
cells
infected
with
either
ME
49
or
RH
strain
and
treated
with
pro-
inflammatory
cytokines
compared
to
anti-
inflammatory
cytokine
treatment
.
The
phosphorylation
of
ERK
1
/
2
protein
increased
after
24
h
of
infection
only
with
the
RH
strain
.
These
results
suggest
that
opposing
mechanisms
of
interference
in
apoptosis
of
BeWo
cells
after
infection
with
RH
or
ME
49
strains
of
T
.
gondii
can
be
associated
with
the
differential
cytokine
profile
secreted
,
the
Fas
/
CD
9
5
expression
and
the
phosphorylated
ERK
1
/
2
expression
.
Diseases
Validation
Diseases presenting
"predominantly pro-inflammatory cytokine profile"
symptom
congenital toxoplasmosis
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