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Congenital toxoplasmosis in a reference center of Paraná, Southern Brazil.
[congenital toxoplasmosis]
This
study
describes
the
characteristics
of
31
children
with
congenital
toxoplasmosis
children
admitted
to
the
University
Hospital
of
Londrina
,
Southern
Brazil
,
from
2000
to
2010
.
In
total
,
23
(
85
.
2
%
)
of
the
mothers
received
prenatal
care
but
only
four
(
13
.
0
%
)
were
treated
for
toxoplasmosis
.
Birth
weight
was
<
2500
g
in
37
.
9
%
of
the
infants
.
During
the
first
month
of
life
,
physical
examination
was
normal
in
34
.
5
%
,
and
for
those
with
clinical
signs
and
symptoms
,
the
main
manifestations
were
hepatomegaly
and
/
or
splenomegaly
(
62
.
1
%
)
,
jaundice
(
13
.
8
%
)
,
and
microcephaly
(
6
.
9
%
)
.
During
ophthalmic
examination
,
74
.
2
%
of
the
children
exhibited
injuries
,
58
.
1
%
chorioretinitis
,
32
.
3
%
strabismus
,
19
.
4
%
microphthalmia
,
and
16
.
2
%
vitreitis
.
Anti-
Toxoplasma
gondii
IgM
antibodies
were
detected
in
48
.
3
%
of
the
children
.
Imaging
brain
evaluation
was
normal
in
44
.
8
%
;
brain
calcifications
,
hydrocephaly
,
or
both
conditions
were
observed
in
27
.
6
%
,
10
.
3
%
,
and
17
.
2
%
,
respectively
,
of
the
patients
.
Patients
with
cerebrospinal
fluid
protein
≥
200
mg
/
dL
presented
more
brain
calcifications
(
p
=
0
.
0325
)
.
Other
sequelae
were
visual
impairment
(
55
.
2
%
of
the
cases
)
,
developmental
delay
(
31
.
0
%
)
,
motor
deficit
(
13
.
8
%
)
,
convulsion
(
27
.
5
%
)
,
and
attention
deficit
(
10
.
3
%
)
.
All
patients
were
treated
with
sulfadiazine
,
pyrimethamine
,
and
folinic
acid
,
and
55
.
2
%
of
them
exhibited
adverse
effects
.
The
results
demonstrate
the
significance
of
the
early
diagnosis
and
treatment
of
toxoplasmosis
during
pregnancy
to
reduce
congenital
toxoplasmosis
and
its
consequences
.
Diseases
Validation
Diseases presenting
"early diagnosis"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
adrenomyeloneuropathy
alexander disease
allergic bronchopulmonary aspergillosis
aromatase deficiency
carcinoma of the gallbladder
cholangiocarcinoma
classical phenylketonuria
coats disease
cohen syndrome
congenital adrenal hyperplasia
congenital diaphragmatic hernia
congenital toxoplasmosis
cowden syndrome
cushing syndrome
cutaneous mastocytosis
cystinuria
dentin dysplasia
dentinogenesis imperfecta
dracunculiasis
erdheim-chester disease
erythropoietic protoporphyria
esophageal carcinoma
esophageal squamous cell carcinoma
fabry disease
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
hirschsprung disease
holt-oram syndrome
homocystinuria without methylmalonic aciduria
hydrocephalus with stenosis of the aqueduct of sylvius
inclusion body myositis
kabuki syndrome
kallmann syndrome
kindler syndrome
krabbe disease
locked-in syndrome
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
omenn syndrome
oral submucous fibrosis
papillon-lefèvre syndrome
phenylketonuria
primary effusion lymphoma
primary hyperoxaluria type 1
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
scrub typhus
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
thoracic outlet syndrome
triple a syndrome
typhoid
von hippel-lindau disease
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
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