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Th1 and Th2 immune response to P30 and ROP18 peptides in human toxoplasmosis.
[congenital toxoplasmosis]
We
determined
the
specific
lymphocyte
proliferative
response
and
cytokine
profile
production
regarding
Toxoplasma
P
30
(
2017
from
virulent
and
non-virulent
strain
)
and
ROP
18
protein-derived
peptides
(
from
clonal
lineages
I
,
II
and
III
)
in
19
patients
having
ocular
toxoplasmosis
,
five
suffering
chronic
asymptomatic
infection
,
nine
with
congenital
toxoplasmosis
and
eight
Toxoplasma
negative
people
.
A
Beckman
Coulter
FC
500
flow
cytometer
was
used
for
determining
antigen-
specific
T
cells
(
CD
3
+
CD
4
+
or
CD
3
+
CD
8
+
cells
)
in
peripheral
blood
culture
.
IFN
γ
and
IL
10
levels
were
determined
in
culture
supernatants
.
Specific
CD
4
+
and
CD
8
+
T
cell
response
to
total
antigen
and
P
30
-
and
ROP
18
-
derived
peptides
was
observed
in
infected
people
.
Ocular
toxoplasmosis
patients
had
a
preferential
Th
2
response
after
antigenic
stimulation
.
Non-virulent
peptide
2017
was
able
to
shift
response
toward
Th
1
in
congenitally
infected
children
and
virulent
peptide
2017
induced
a
Th
2
response
in
chronically
infected
,
asymptomatic
people
.
An
immune
response
in
human
toxoplasmosis
after
ex
vivo
antigenic
stimulation
was
Th
1
-
or
Th
2
-
skewed
,
depending
on
a
patient
's
clinical
condition
.
Colombian
ocular
toxoplasmosis
patients
'
immune
response
was
Th
2
-
skewed
,
regardless
of
the
nature
of
antigen
stimulus
.
Diseases
Validation
Diseases presenting
"five suffering chronic asymptomatic infection"
symptom
congenital toxoplasmosis
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