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[Congenital and perinatal infections in the Marche region (Italy): an epidemiological study and differences between ethnic groups].
[congenital toxoplasmosis]
The
purpose
of
this
study
was
to
evaluate
the
epidemiological
data
regarding
congenital
and
perinatal
infections
in
the
Marche
region
to
verify
the
existence
of
differences
in
relation
to
maternal
country
of
origin
.
This
prospective
study
was
conducted
from
May
2001
to
April
2012
,
and
it
involved
all
the
maternity
units
of
the
Marche
region
.
A
total
of
10232
pregnant
women
were
included
,
25
.
1
%
of
whom
were
of
foreign
nationality
while
the
number
of
births
totalled
10371
.
Estimated
uptake
of
antenatal
screening
was
80
.
5
%
for
CMV
infection
,
98
.
6
%
for
HBV
infection
,
97
.
5
%
for
HCV
infection
,
97
.
4
%
for
HIV
infection
,
93
.
1
%
for
syphilis
and
98
.
5
%
for
toxoplasmosis
.
For
group
B
streptococcus
vaginal
and
perianal
swabs
were
performed
in
81
.
2
%
of
all
women
(
78
.
4
%
in
immigrant
and
90
.
4
%
in
Italian
women
;
the
difference
was
statistically
significant
[
p
0
.
001
]
)
and
13
.
6
%
were
positive
.
The
overall
prevalence
for
CMV
infection
was
72
.
3
%
(
91
.
9
%
in
immigrant
women
)
while
for
toxoplasmosis
it
was
27
.
5
%
(
28
.
8
%
in
immigrant
women
)
.
The
rate
of
seroconversion
in
pregnant
women
investigated
for
CMV
infection
was
0
.
28
%
,
while
that
for
toxoplasmosis
was
0
.
09
%
.
The
overall
prevalence
for
HBV
infection
was
0
.
79
%
(
4
.
3
%
in
immigrant
and
0
.
4
%
in
Italian
pregnant
women
;
the
difference
was
statistically
significant
[
p
0
.
001
]
)
,
0
.
4
%
for
HCV
infection
(
1
%
in
immigrant
and
0
.
48
%
in
Italian
pregnant
women
;
the
difference
was
not
statistically
significant
[
p
0
.
413
]
)
,
0
.
22
%
for
syphilis
(
0
.
8
%
in
immigrant
and
0
.
08
%
in
Italian
pregnant
women
;
the
difference
was
not
statistically
significant
[
p
0
.
062
]
)
,
0
.
09
%
for
HIV
infection
,
and
0
.
03
%
for
tuberculosis
.
The
prevalence
of
congenital
CMV
infection
was
0
.
04
%
and
that
of
congenital
toxoplasmosis
0
.
01
%
.
The
prevalence
of
early
-onset
infection
from
Group
B
streptococcus
was
0
.
029
%
.
No
cases
were
observed
of
congenital
syphilis
,
congenital
tuberculosis
or
maternal
and
neonatal
HSV
infections
.
The
study
proves
that
in
the
Marche
region
there
is
a
high
percentage
of
women
who
undergo
prenatal
screening
,
including
screening
for
infections
,
not
offered
by
the
National
Health
Service
,
such
as
CMV
and
HCV
.
The
data
also
demonstrate
that
some
infections
,
such
as
tuberculosis
,
HIV
and
HBV
,
almost
exclusively
affect
immigrant
women
.
Regarding
neonatal
infections
,
the
data
presented
are
in
line
with
those
in
the
literature
,
with
the
exception
of
congenital
CMV
infection
,
in
which
the
low
prevalence
observed
could
be
linked
to
the
recent
and
massive
migration
of
already
immunized
women
.
Diseases
Validation
Diseases presenting
"high percentage"
symptom
cholangiocarcinoma
cohen syndrome
congenital toxoplasmosis
cystinuria
familial mediterranean fever
lamellar ichthyosis
neonatal adrenoleukodystrophy
trochlear dysplasia
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