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Biomarker analysis revealed distinct profiles of innate and adaptive immunity in infants with ocular lesions of congenital toxoplasmosis.
[congenital toxoplasmosis]
Toxoplasma
gondii
is
the
main
infectious
cause
of
human
posterior
retinochoroiditis
,
the
most
frequent
clinical
manifestation
of
congenital
toxoplasmosis
.
This
investigation
was
performed
after
neonatal
screening
to
identify
biomarkers
of
immunity
associated
with
immunopathological
features
of
the
disease
by
flow
cytometry
.
The
study
included
infected
infants
without
NRL
and
with
retinochoroidal
lesions
(
ARL
,
ACRL
,
and
CRL
)
as
well
as
noninfected
individuals
(
NI
)
.
Our
data
demonstrated
that
leukocytosis
,
with
increased
monocytes
and
lymphocytes
,
was
a
relevant
hematological
biomarker
of
ARL
.
Immunophenotypic
analysis
also
revealed
expansion
of
CD
14
(
+
)
CD
16
(
+
)
HLA-
DR
(
high
)
monocytes
and
CD
5
6
(
dim
)
cytotoxic
NK-cells
in
ARL
.
Moreover
,
augmented
TCR
γ
δ
(
+
)
and
CD
8
(
+
)
T
-
cell
counts
were
apparently
good
biomarkers
of
morbidity
.
Biomarker
network
analysis
revealed
that
complex
and
intricated
networks
underscored
the
negative
correlation
of
monocytes
with
NK-
and
B-
cells
in
NRL
.
The
remarkable
lack
of
connections
involving
B-
cells
and
a
relevant
shift
of
NK-cell
connections
from
B-
cells
toward
T
-
cells
observed
in
ARL
were
outstanding
.
A
tightly
connected
biomarker
network
was
observed
in
CRL
,
with
relevant
connections
of
NK-
and
CD
8
(
+
)
T
-
cells
with
a
broad
range
of
cell
subsets
.
Our
findings
add
novel
elements
to
the
current
knowledge
on
the
innate
and
adaptive
immune
responses
in
congenital
toxoplasmosis
.
Diseases
Validation
Diseases presenting
"broad range"
symptom
acute rheumatic fever
congenital toxoplasmosis
cowden syndrome
cystinuria
dystrophic epidermolysis bullosa
gm1 gangliosidosis
hereditary cerebral hemorrhage with amyloidosis
kallmann syndrome
neuralgic amyotrophy
severe combined immunodeficiency
typhoid
waldenström macroglobulinemia
well-differentiated liposarcoma
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