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A New Sonographic Weight Estimation Formula for Fetuses with Congenital Diaphragmatic Hernia.
[congenital diaphragmatic hernia]
Purpose
:
The
accuracy
of
the
sonographic
weight
estimation
(
WE
)
of
fetuses
with
congenital
diaphragmatic
hernia
(
CDH
)
is
significantly
lower
than
that
of
fetuses
without
any
malformations
.
The
objective
of
this
study
was
to
develop
and
evaluate
the
first
specific
sonographic
weight
formula
for
fetuses
with
CDH
.
Materials
and
Methods
:
In
a
retrospective
,
multicenter
,
cohort
study
,
a
statistical
estimation
technique
known
as
"
multivariable
fractional
polynomial
regression
"
was
applied
to
a
group
of
146
fetuses
with
CDH
.
Each
fetus
underwent
an
ultrasound
examination
with
complete
biometric
parameters
within
7
days
of
delivery
.
A
new
formula
was
derived
using
the
obtained
data
and
was
then
compared
with
other
commonly
used
equations
.
The
accuracy
of
the
different
formulas
was
compared
using
means
of
signed
percentage
errors
(
SPE
)
,
medians
of
absolute
percentage
errors
(
MAPE
)
,
and
fractions
of
estimates
within
prespecified
error
bounds
.
Results
:
The
new
derived
formula
is
:
EFW
=
10
^
(
4
.
6729
107
371
+
0
.
2365
011
768
*
HC
+
0
.
2228
897
682
*
FL
^
2
-
0
.
0129
895
773
*
FL
^
3
-
1
.
0470
039
072
*
(
FL
*
HC
)
^
0
.
5
+
0
.
0004
314
661
*
(
AC
*
HC
)
-
[
in
case
of
liver
herniation
]
0
.
0062
112
122
)
,
where
EFW
is
the
estimated
fetal
weight
,
HC
is
the
head
circumference
,
AC
is
the
abdominal
circumference
,
and
FL
is
the
femur
length
.
The
new
formula
proved
to
be
superior
to
other
established
equations
,
showing
both
the
lowest
median
absolute
percentage
error
(
MAE
:
6
.
97
)
and
mean
signed
percentage
error
(
SPE
:
0
.
40
)
,
and
the
best
distribution
of
absolute
percentage
errors
within
prespecified
error
bounds
.
Conclusion
:
This
new
formula
significantly
improves
weight
estimation
in
fetuses
with
CDH
.
Diseases
Validation
Diseases presenting
"first specific sonographic weight formula"
symptom
congenital diaphragmatic hernia
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