Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Safety of epoprostenol and treprostinil in children less than 12 months of age.
[congenital diaphragmatic hernia]
There
is
a
paucity
of
data
on
infant
intravenous
prostacyclin
use
,
the
gold
standard
for
therapy
for
severe
pulmonary
hypertension
(
PH
)
.
This
review
aimed
to
evaluate
the
safety
,
tolerability
,
and
outcomes
of
infant
prostacyclin
use
.
A
retrospective
observational
study
was
performed
in
a
large
pediatric
hospital
with
a
dedicated
pediatric
PH
program
.
Subject
medical
records
,
bedside
flow
sheets
,
and
progress
notes
were
reviewed
to
identify
use
of
intravenous
epoprostenol
or
treprostinil
within
the
first
year
of
life
.
The
indication
for
prostacyclin
use
was
recalcitrant
hemodynamic
compromise
associated
with
PH
,
identified
as
either
idiopathic
PH
,
persistent
PH
of
the
newborn
,
PH
associated
with
congenital
diaphragmatic
hernia
,
congenital
heart
disease
,
bronchiolitis
,
or
chronic
lung
disease
.
Prostacyclin-related
adverse
events
included
7
episodes
of
hypotension
,
6
episodes
of
perceived
pain
,
2
episodes
of
cyanosis
,
and
1
episode
of
feeding
intolerance
.
Prostacyclin
was
stopped
only
for
cyanotic
episodes
associated
with
use
in
severe
chronic
lung
disease
.
Two
hemorrhagic
events
occurred
during
extracorporeal
membrane
oxygenation
,
which
were
unlikely
to
be
prostacyclin
related
.
Outcomes
included
21
deaths
unrelated
to
prostacyclin
,
1
lung
transplant
,
6
PH
resolutions
,
8
transitions
to
oral
PH
medications
,
and
1
continuation
of
treprostinil
.
In
conclusion
,
efficacy
could
not
be
evaluated
in
this
study
because
of
the
loss
of
equipoise
for
neonatal
prostacyclin
use
.
Prostacyclin
use
was
well
tolerated
in
neonatal
diseases
associated
with
PH
,
but
dose
titration
was
limited
by
hypotension
and
hypoxemia
.
Diseases
Validation
Diseases presenting
"but dose titration was limited by hypotension and hypoxemia"
symptom
congenital diaphragmatic hernia
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom