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The lung to thorax transverse area ratio has a linear correlation with the observed to expected lung area to head circumference ratio in fetuses with congenital diaphragmatic hernias.
[congenital diaphragmatic hernia]
The
purpose
of
this
study
was
to
clarify
the
relationship
between
the
lung
to
thorax
transverse
area
ratio
(
L
/
T
ratio
)
and
the
observed
to
expected
lung
area
to
head
circumference
ratio
(
O
/
E
LHR
)
,
based
on
the
results
of
a
nationwide
Japanese
survey
conducted
in
2011
,
and
to
evaluate
the
compatibility
of
these
prognostic
predictors
of
fetal
CDH
.
T
wo
hundred
and
forty-
two
prenatally
diagnosed
isolated
CDH
patients
born
between
2006
and
2010
were
included
in
the
present
analysis
.
A
regression
analysis
was
conducted
to
investigate
the
relationship
between
the
L
/
T
ratio
and
the
O
/
E
LHR
based
on
191
simultaneous
measurements
of
these
parameters
in
120
patients
.
The
linear
regression
equation
between
the
L
/
T
ratio
and
the
O
/
E
LHR
was
:
L
/
T
ratio
=
0
.
0233
+
(
0
.
00222
×
O
/
E
LHR
)
,
(
R
=
0
.
847
,
p
<
0
.
0001
)
.
According
to
this
equation
,
25
%
of
the
O
/
E
LHR
,
the
cut-off
value
used
in
the
fetal
intervention
for
CDH
,
was
equivalent
to
an
L
/
T
ratio
of
0
.
08
,
a
commonly
accepted
cut-off
value
for
identifying
the
most
severe
cases
of
fetal
CDH
.
As
there
is
a
positive
correlation
between
the
L
/
T
ratio
and
the
O
/
E
LHR
,
these
two
parameters
proved
to
be
used
interchangeably
according
to
the
linear
regression
equation
.
Diseases
Validation
Diseases presenting
"severe cases"
symptom
coats disease
congenital diaphragmatic hernia
dentin dysplasia
dentinogenesis imperfecta
erythropoietic protoporphyria
hereditary cerebral hemorrhage with amyloidosis
hydrocephalus with stenosis of the aqueduct of sylvius
locked-in syndrome
megacystis-microcolon-intestinal hypoperistalsis syndrome
neuralgic amyotrophy
proteus syndrome
scrub typhus
trochlear dysplasia
typhoid
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