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Respiratory Syncytial Virus Infection in High-risk Infants - an Update on Palivizumab Prophylaxis.
[congenital diaphragmatic hernia]
Morbidity
due
to
respiratory
syncytial
virus
(
RSV
)
disease
is
still
high
in
infants
and
children
worldwide
during
the
first
two
to
five
years
of
life
.
Certain
categories
of
high
-risk
infants
with
increased
morbidity
and
mortality
attributed
to
RSV
disease
have
been
identified
and
are
included
in
national
recommendations
for
prophylaxis
with
the
monoclonal
RSV
antibody
palivizumab
.
Most
guidelines
recommend
palivizumab
for
preterm
infants
born
less
than
or
equal
to
32
weeks
gestational
age
with
or
without
bronchopulmonary
dysplasia
,
those
born
between
33
and
35
weeks
gestational
age
with
additional
risk
factors
,
and
infants
and
children
with
hemodynamically
significant
congenital
heart
disease
.
Over
the
last
years
several
rare
diseases
have
been
identified
demonstrating
high
morbidity
associated
with
RSV
disease
,
thus
,
extension
of
guidelines
for
the
prophylaxis
with
palivizumab
for
these
patients
with
rare
diseases
including
children
with
malignancy
,
congenital
and
acquired
immune
deficiency
,
Down
syndrome
,
neuromuscular
impairment
,
cystic
fibrosis
,
congenital
diaphragmatic
hernia
and
other
severe
respiratory
disease
is
increasingly
discussed
.
Efficacy
of
palivizumab
prophylaxis
is
documented
by
meta
-analysis
,
and
different
economic
analyses
demonstrate
cost-effectiveness
of
palivizumab
for
the
most
common
indications
during
the
first
RSV
season
.
Diseases
Validation
Diseases presenting
"heart disease"
symptom
22q11.2 deletion syndrome
achondroplasia
acute rheumatic fever
adrenal incidentaloma
child syndrome
classical phenylketonuria
cohen syndrome
congenital diaphragmatic hernia
dentinogenesis imperfecta
esophageal adenocarcinoma
fabry disease
familial mediterranean fever
heparin-induced thrombocytopenia
hirschsprung disease
holt-oram syndrome
homocystinuria without methylmalonic aciduria
kabuki syndrome
monosomy 21
omenn syndrome
phenylketonuria
sneddon syndrome
systemic capillary leak syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
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