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Standardization of pulmonary ventilation technique using volume-controlled ventilators in rats with congenital diaphragmatic hernia.
[congenital diaphragmatic hernia]
To
standardize
a
technique
for
ventilating
rat
fetuses
with
Congenital
Diaphragmatic
Hernia
(
CDH
)
using
a
volume-controlled
ventilator
.
Pregnant
rats
were
divided
into
the
following
groups
:
a
)
control
(
C
)
;
b
)
exposed
to
nitrofen
with
CDH
(
CDH
)
;
and
c
)
exposed
to
nitrofen
without
CDH
(
N-
)
.
Fetuses
of
the
three
groups
were
randomly
divided
into
the
subgroups
ventilated
(
V
)
and
non-ventilated
(
N-V
)
.
Fetuses
were
collected
on
day
21
.
5
of
gestation
,
weighed
and
ventilated
for
30
minutes
using
a
volume-controlled
ventilator
.
Then
the
lungs
were
collected
for
histological
study
.
We
evaluated
:
body
weight
(
BW
)
,
total
lung
weight
(
TLW
)
,
left
lung
weight
(
LLW
)
,
ratios
TLW
/
BW
and
LLW
/
BW
,
morphological
histology
of
the
airways
and
causes
of
failures
of
ventilation
.
BW
,
TLW
,
LLW
,
TLW
/
BW
and
LLW
/
BW
were
higher
in
C
compared
with
N-
(
p
<
0
.
05
)
and
CDH
(
p
<
0
.
05
)
,
but
no
differences
were
found
between
the
subgroups
V
and
N-V
(
p
>
0
.
05
)
.
The
morphology
of
the
pulmonary
airways
showed
hypoplasia
in
groups
N-
and
CDH
,
with
no
difference
between
V
and
N-V
(
p
<
0
.
05
)
.
The
C
and
N-
groups
could
be
successfully
ventilated
using
a
tidal
volume
of
75
ìl
,
but
the
failure
of
ventilation
in
the
CDH
group
decreased
only
when
ventilated
with
50
ìl
.
Volume
ventilation
is
possible
in
rats
with
CDH
for
a
short
period
and
does
not
alter
fetal
or
lung
morphology
.
Diseases
Validation
Diseases presenting
"causes of failures of ventilation"
symptom
congenital diaphragmatic hernia
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