Neonatal gastric perforation: A single center experience.

[congenital diaphragmatic hernia]

To determine the etiology and prognostic factors for neonatal gastric perforation (NGP ), a rare but life-threatening disease .Between 1980 and 2011 , nine patients underwent surgical intervention for NGP at Seoul National University Children 's Hospital . The characteristics and prognosis of the patients were retrospectively analyzed .Among the nine patients , three (33 .3 %) were preterm babies and five (55 .5 %) had associated anomalies , which included diaphragmatic eventration (n = 2 ), congenital diaphragmatic hernia , esophageal atresia with tracheoesophageal fistula , and antral web . Three (33 .3 %) patients were born before 1990 and three (33 .3 %) had a birth weight < 2500 g . Pneumoperitoneum was found on preoperative images in six (66 .7 %) patients , and incidentally in the other three (33 .3 %) patients . Surgery was performed within 24 h after the onset of symptoms in seven (77 .8 %) patients . The overall mortality rate was 22 .2 % (2 /9 ). The time between symptoms and surgical intervention was the only prognostic factor for survival , whereas premature birth and birth weight were not .Early detection and advances in neonatal intensive care may improve the prognosis of NGP .

Diseases
Validation

Diseases presenting "early detection" symptom

22q11.2 deletion syndrome

acute rheumatic fever

adrenomyeloneuropathy

allergic bronchopulmonary aspergillosis

carcinoma of the gallbladder

child syndrome

cholangiocarcinoma

classical phenylketonuria

congenital diaphragmatic hernia

cowden syndrome

cystinuria

erythropoietic protoporphyria

esophageal adenocarcinoma

esophageal squamous cell carcinoma

fabry disease

homocystinuria without methylmalonic aciduria

inclusion body myositis

kallmann syndrome

krabbe disease

oral submucous fibrosis

papillon-lefèvre syndrome

phenylketonuria

pyomyositis

von hippel-lindau disease

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