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Procalcitonin as a marker of respiratory disorder in neonates.
[congenital diaphragmatic hernia]
Serum
procalcitonin
(
PCT
)
increases
in
various
respiratory
disorders
such
as
acuterespiratory
distress
syndrome
.
Elevated
PCT
levels
are
also
observed
in
healthy
neonates
.
In
this
study
,
we
analyzed
if
PCT
levels
were
good
markers
of
respiratory
disorders
in
neonates
.
A
total
of
155
neonates
with
or
without
respiratory
disorders
,
were
eligible
for
the
study
.
PCT
level
was
measured
by
performing
electrochemiluminescence
immunoassay
.
Each
neonate
was
allocated
to
the
non-
respiratory
disorder
(
control
)
group
(
n
=
95
)
,
or
a
respiratory
disorder
group
(
n
=
60
)
.
PCT
levels
were
compared
between
both
groups
,
and
association
with
other
markers
,
including
C-
reactive
protein
(
CRP
)
and
white
blood
cell
(
WBC
)
count
,
was
analyzed
.
The
60
neonates
in
the
respiratory
disorder
group
comprised
39
,
10
,
5
,
1
,
2
,
2
,
and
1
neonates
with
transient
tachypnea
of
the
newborn
,
respiratory
distress
syndrome
,
air
leak
syndrome
,
meconium
aspiration
syndrome
,
18
-
trisomy
,
neonatal
asphyxia
,
and
congenital
diaphragmatic
hernia
,
respectively
.
Mean
PCT
and
CRP
levels
and
WBC
counts
in
the
respiratory
disorder
group
were
9
.
01
ng
/
mL
,
0
.
26
mg
/
dL
,
and
16
,
100
cells
/
μL
,
respectively
.
The
area
under
the
curve
obtained
for
PCT
in
distinguishing
between
the
respiratory
disorder
and
control
groups
was
0
.
85
(
sensitivity
,
66
.
7
%
;
specificity
,
93
.
0
%
;
optimum
cutoff
,
3
.
73
ng
/
mL
)
,
for
CRP
it
was
0
.
72
(
sensitivity
,
75
.
0
%
;
specificity
,
64
.
6
%
;
optimum
cutoff
,
0
.
14
mg
/
dL
)
,
and
for
WBC
it
was
0
.
44
(
sensitivity
,
60
.
0
%
;
specificity
,
29
.
6
%
;
optimum
cutoff
,
15
,
000
cells
/
μL
)
.
PCT
is
more
susceptible
as
a
diagnostic
parameter
of
infection
to
the
effect
of
respiratory
disturbance
than
CRP
and
WBC
.
Diseases
Validation
Diseases presenting
"blood cell"
symptom
allergic bronchopulmonary aspergillosis
alpha-thalassemia
cholangiocarcinoma
congenital diaphragmatic hernia
esophageal squamous cell carcinoma
familial mediterranean fever
oculocutaneous albinism
phenylketonuria
pyomyositis
scrub typhus
severe combined immunodeficiency
zellweger syndrome
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