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Neurodevelopmental outcome in congenital diaphragmatic hernia: Evaluation, predictors and outcome.
[congenital diaphragmatic hernia]
To
review
the
reported
neurodevelopmental
outcome
of
congenital
diaphragmatic
hernia
(
CDH
)
survivors
,
identify
important
predictors
of
developmental
disabilities
,
and
describe
the
pathophysiological
mechanisms
contributing
to
adverse
outcome
.
A
Medline
search
was
performed
for
English
-
language
articles
cross-referencing
CDH
with
pertinent
search
terms
.
Retrospective
,
prospective
,
and
longitudinal
follow-up
studies
were
examined
.
The
reference
lists
of
identified
articles
were
also
searched
.
Neurodevelopmental
dysfunction
has
been
recognized
as
one
of
most
common
and
potentially
most
disabling
outcome
of
CDH
.
Intelligence
appears
to
be
in
the
low
normal
to
mildly
delayed
range
.
Neuromotor
dysfunction
is
common
during
early
childhood
.
Behavioral
problems
,
hearing
impairment
,
and
quality
of
life
related
issues
are
frequently
encountered
in
older
children
and
adolescence
.
Disease
severity
correlates
with
the
degree
of
neurological
dysfunction
.
Neurodevelopmental
follow-up
in
CDH
children
should
become
standard
of
care
to
identify
those
who
would
benefit
from
early
intervention
services
and
improve
neurological
outcomes
.