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Full thickness abdominal wall defect in growing rats as a model for congenital diaphragmatic hernia prosthetic repair.
[congenital diaphragmatic hernia]
Large
congenital
diaphragmatic
hernia
may
require
prosthetic
correction
.
Acellular
collagen
matrices
were
introduced
to
avoid
complications
owing
to
the
use
of
synthetic
patches
.
We
tested
3
different
ACM
for
reconstruction
of
an
abdominal
wall
defect
in
an
animal
model
that
mimics
the
fast
growth
during
infancy
.
Pelvisoft
®
(
CR
Bard
,
Covington
,
GA
)
and
2
investigational
ACM
were
used
for
primary
reconstruction
of
a
full
thickness
abdominal
wall
defect
.
3
months
-old
rats
(
n
=
26
)
were
allowed
to
survive
for
90
days
after
implantation
.
Anatomical
,
tensiometric
and
histological
analyses
were
performed
.
Based
on
good
outcomes
,
we
did
the
same
with
1
month
-old
rats
(
n
=
54
)
.
Unoperated
rats
were
used
for
obtaining
reference
tensiometric
values
of
selected
native
tissues
.
Major
wound
complications
were
exclusively
observed
in
1
month
-old
rats
.
All
explants
in
both
groups
thinned
significantly
(
p
<
0
.
03
)
and
had
an
elastic
modulus
increasing
over
time
,
far
above
that
from
native
tissues
at
90
days
of
life
.
Both
investigational
ACM
induced
a
more
vigorous
foreign
body
reaction
than
Pelvisoft
(
®
)
.
The
shift
from
3
to
1
month
-old
rats
was
associated
with
wound
complications
.
Pelvisoft
®
showed
a
better
biocompatibility
than
the
2
investigational
ACM
.
Passive
biomechanical
properties
of
all
explants
were
still
not
comparable
to
that
of
native
tissues
.
Diseases
Validation
Diseases presenting
"wound complications"
symptom
congenital diaphragmatic hernia
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