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Performance of phalangeal quantitative ultrasound parameters in the evaluation of reduced bone mineral density assessed by DX in patients with 21 hydroxylase deficiency.
[congenital adrenal hyperplasia]
The
purpose
of
this
study
was
to
verify
the
performance
of
quantitative
ultrasound
(
QUS
)
parameters
of
proximal
phalanges
in
the
evaluation
of
reduced
bone
mineral
density
(
BMD
)
in
patients
with
congenital
adrenal
hyperplasia
due
to
21
-
hydroxylase
deficiency
(
21
OHD
)
.
Seventy
patients
with
21
OHD
(
41
females
and
29
males
)
,
aged
between
6
-
27
y
were
assessed
.
The
QUS
measurements
,
amplitude-dependent
speed
of
sound
(
AD
-SoS
)
,
bone
transmission
time
(
BTT
)
,
and
ultrasound
bone
profile
index
(
UBPI
)
were
obtained
using
the
BMD
Sonic
device
(
IGEA
,
Carpi
,
Italy
)
on
the
last
four
proximal
phalanges
in
the
non-dominant
hand
.
BMD
was
determined
by
dual
energy
X-
ray
(
DXA
)
across
the
total
body
and
lumbar
spine
(
LS
)
.
Total
body
and
LS
BMD
were
positively
correlated
to
UBPI
,
BTT
and
AD
-SoS
(
correlation
coefficients
ranged
from
0
.
59
-
0
.
72
,
p
<
0
.
001
)
.
In
contrast
,
when
comparing
patients
with
normal
and
low
(
Z-
score
<
-
2
)
BMD
,
no
differences
were
found
in
the
QUS
parameters
.
Furthermore
,
UBPI
,
BTT
and
AD
-SoS
measurements
were
not
effective
for
diagnosing
patients
with
reduced
BMD
by
receiver
operator
characteristic
curve
parameters
.
Although
the
AD
-SoS
,
BTT
and
UBPI
showed
significant
correlations
with
the
data
obtained
by
DXA
,
they
were
not
effective
for
diagnosing
reduced
bone
mass
in
patients
with
21
OHD
.
Diseases
Validation
Diseases presenting
"bone profile index"
symptom
congenital adrenal hyperplasia
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