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Serum AMH levels in the differential diagnosis of hyperandrogenemic conditions.
[congenital adrenal hyperplasia]
To
investigate
the
diagnostic
potential
of
anti-
Müllerian
hormone
(
AMH
)
in
the
differential
diagnosis
of
various
hyperandrogenemic
conditions
.
Among
2241
consecutive
women
of
reproductive
age
who
were
seen
at
a
tertiary
care
university
hospital
with
complaints
of
acne
,
hirsutism
,
androgenetic
alopecia
,
and
menstrual
dysfunction
(
oligomenorrhea
and
/
or
amenorrhea
)
,
107
patients
with
serum
17
α-hydroxyprogesterone
(
17
α-
OHP
)
levels
higher
than
2
ng
/
ml
were
recruited
for
this
study
.
An
ACTH
stimulation
test
was
performed
,
and
basal
serum
hormonal
parameters
and
AMH
levels
were
measured
for
all
patients
.
25
patients
were
diagnosed
with
late-onset
congenital
adrenal
hyperplasia
(
LOCAH
)
,
and
59
patients
with
polycystic
ovary
syndrome
(
PCOS
)
had
significantly
higher
serum
AMH
levels
than
all
other
groups
.
Among
hyperandrogenemic
patients
with
serum
17
α-
OHP
levels
>
2
ng
/
ml
,
serum
AMH
levels
might
be
introduced
as
a
marker
to
be
utilized
clinically
in
the
differential
diagnosis
of
hyperandrogenemic
patients
,
especially
for
identifying
patients
with
PCOS
.
Diseases
Validation
Diseases presenting
"polycystic ovary syndrome"
symptom
aromatase deficiency
congenital adrenal hyperplasia
cushing syndrome
kallmann syndrome
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