Serum AMH levels in the differential diagnosis of hyperandrogenemic conditions.

[congenital adrenal hyperplasia]

To investigate the diagnostic potential of anti-Müllerian hormone (AMH ) in the differential diagnosis of various hyperandrogenemic conditions .Among 2241 consecutive women of reproductive age who were seen at a tertiary care university hospital with complaints of acne , hirsutism , androgenetic alopecia , and menstrual dysfunction (oligomenorrhea and /or amenorrhea ), 107 patients with serum 17 α-hydroxyprogesterone (17 α-OHP ) levels higher than 2 ng /ml were recruited for this study . An ACTH stimulation test was performed , and basal serum hormonal parameters and AMH levels were measured for all patients .25 patients were diagnosed with late-onset congenital adrenal hyperplasia (LOCAH ), and 59 patients with polycystic ovary syndrome (PCOS ) had significantly higher serum AMH levels than all other groups .Among hyperandrogenemic patients with serum 17 α-OHP levels >2 ng /ml , serum AMH levels might be introduced as a marker to be utilized clinically in the differential diagnosis of hyperandrogenemic patients , especially for identifying patients with PCOS .