Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Otoacoustic emissions, auditory evoked potentials and self-reported gender in people affected by disorders of sex development (DSD).
[congenital adrenal hyperplasia]
Both
otoacoustic
emissions
(
OAEs
)
and
auditory
evoked
potentials
(
AEPs
)
are
sexually
dimorphic
,
and
both
are
believed
to
be
influenced
by
prenatal
androgen
exposure
.
OAEs
and
AEPs
were
collected
from
people
affected
by
1
of
3
categories
of
disorders
of
sex
development
(
DSD
)
-
(
1
)
women
with
complete
androgen
insensitivity
syndrome
(
CAIS
)
;
(
2
)
women
with
congenital
adrenal
hyperplasia
(
CAH
)
;
and
(
3
)
individuals
with
46
,
XY
DSD
including
prenatal
androgen
exposure
who
developed
a
male
gender
despite
initial
rearing
as
females
(
men
with
DSD
)
.
Gender
identity
(
GI
)
and
role
(
GR
)
were
measured
both
retrospectively
and
at
the
time
of
study
participation
,
using
standardized
questionnaires
.
The
main
objective
of
this
study
was
to
determine
if
patterns
of
OAEs
and
AEPs
correlate
with
gender
in
people
affected
by
DSD
and
in
controls
.
A
second
objective
was
to
assess
if
OAE
and
AEP
patterns
differed
according
to
degrees
of
prenatal
androgen
exposure
across
groups
.
Control
males
,
men
with
DSD
,
and
women
with
CAH
produced
fewer
spontaneous
OAEs
(
SOAEs
)
-
the
male-typical
pattern
-
than
control
females
and
women
with
CAIS
.
Additionally
,
the
number
of
SOAEs
produced
correlated
with
gender
development
across
all
groups
tested
.
Although
some
sex
differences
in
AEPs
were
observed
between
control
males
and
females
,
AEP
measures
did
not
correlate
with
gender
development
,
nor
did
they
vary
according
to
degrees
of
prenatal
androgen
exposure
,
among
people
with
DSD
.
Thus
,
OAEs
,
but
not
AEPs
,
may
prove
useful
as
bioassays
for
assessing
early
brain
exposure
to
androgens
and
predicting
gender
development
in
people
with
DSD
.
Diseases
Validation
Diseases presenting
"among people with dsd"
symptom
congenital adrenal hyperplasia
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom