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Gestational diabetes mellitus risk factors in women with polycystic ovary syndrome (PCOS).
[congenital adrenal hyperplasia]
To
compare
the
incidence
of
gestational
diabetes
mellitus
(
GDM
)
in
Iranian
infertile
women
with
polycystic
ovary
syndrome
(
PCOS
)
and
women
without
PCOS
after
pregnancies
resulting
from
either
assisted
reproductive
technology
(
ART
)
or
spontaneous
as
well
as
to
determine
the
risk
factors
of
GDM
in
PCOS
women
.
In
a
cross-sectional
study
,
we
evaluated
medical
records
of
234
spontaneous
pregnant
women
without
PCOS
in
Akbarabadi
Women
's
Hospital
affiliated
to
Tehran
University
of
Medical
Science
,
Tehran
,
Iran
,
along
with
234
pregnant
women
with
PCOS
and
234
pregnant
non-
PCOS
women
with
ART
conception
who
were
treated
at
Royan
institute
,
Tehran
,
Iran
,
at
the
same
period
of
time
,
2012
to
February
2013
.
Exclusion
criteria
were
as
following
:
maternal
age
≥
40
,
family
history
of
diabetes
in
first
-degree
relatives
,
pre-pregnancy
diabetes
and
history
of
gestational
diabetes
,
history
of
stillbirth
,
recurrent
miscarriage
,
birth
weight
baby
≥
4
kg
(
macrosomia
)
,
parity
>
4
,
Cushing
's
syndrome
,
congenital
adrenal
hyperplasia
and
overt
hypothyroidism
.
The
GDM
diagnosis
was
according
to
American
Diabetes
Association
(
ADA
)
criteria
.
Incidence
and
the
risk
factors
for
GDM
were
evaluated
.
The
incidence
rates
of
GDM
were
44
.
4
%
,
29
.
9
%
and
7
.
3
%
for
PCOS
ART
,
non-
PCOS
ART
and
non-
PCOS
spontaneous
pregnant
women
,
respectively
.
Multivariable
logistic
regression
was
used
for
determining
risk
factors
of
GDM
in
PCOS
women
with
adjusted
odds
ratios
for
age
,
parity
and
hypothyroidism
,
the
results
revealed
the
most
important
and
significant
predictors
for
development
of
GDM
in
PCOS
women
as
follow
:
menstrual
irregularity
(
OR
=
4
.
2
;
95
%
CI
=
1
.
7
-
10
.
6
)
,
serum
triglycerides
level
≥
150
mg
/
dL
(
OR
=
1
.
9
;
95
%
CI
=
1
.
07
-
3
.
6
)
and
pregestational
metformin
use
(
OR
=
0
.
4
;
95
%
CI
=
0
.
2
-
0
.
7
)
.
Pregnant
Iranian
women
with
a
history
of
infertility
and
PCOS
are
at
increased
risk
for
developing
GDM
.
It
is
recommendable
to
perform
screening
test
for
GDM
in
PCOS
women
with
ART
treatment
,
irregular
menses
and
high
serum
triglycerides
level
in
the
early
stage
of
pregnancy
.
Pregestational
use
of
metformin
can
be
effective
in
reducing
the
occurrence
of
GDM
.
Diseases
Validation
Diseases presenting
"high serum triglycerides level in the early stage of pregnancy"
symptom
congenital adrenal hyperplasia
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