Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Health-related quality of life in primary and secondary adrenal insufficiency.
[congenital adrenal hyperplasia]
Adrenal
insufficiency
(
AI
)
is
characterized
by
a
deficient
production
of
glucocorticoids
with
or
without
associated
mineralcorticoid
and
/
or
adrenal
androgen
deficiencies
.
Despite
the
low
prevalence
of
AI
,
its
impact
on
the
affected
patient
is
very
high
,
and
can
be
life-threatening
disease
if
not
adequately
treated
.
Several
glucocorticoid
treatment
regimens
are
available
,
but
none
is
capable
of
perfectly
imitating
the
cortisol
circadian
rhythm
.
Cortisol
rhythmicity
and
treatment
of
other
possible
concomitant
conditions
often
associated
(
e
.
g
.
,
autoimmune
disorders
and
panhypopituitarism
)
are
essential
to
improve
outcome
of
AI
.
Morbidity
often
present
in
treated
AI
include
an
unhealthy
metabolic
profile
,
bad
quality
of
sleep
,
infertility
,
sexual
dysfunction
and
worse
health-related
quality
of
life
.
This
review
focuses
on
psychological
morbidity
and
impaired
quality
of
life
in
patients
with
primary
or
secondary
AI
of
any
origin
,
including
a
special
section
devoted
to
congenital
adrenal
hyperplasia
.
