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A random Abstract
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Genetic obesity syndromes.
[cohen syndrome]
There
are
numerous
reports
of
multi-system
genetic
disorders
with
obesity
.
Many
have
a
characteristic
presentation
and
several
,
an
overlapping
phenotype
indicating
the
likelihood
of
a
shared
common
underlying
mechanism
or
pathway
.
By
understanding
the
genetic
causes
and
functional
perturbations
of
such
syndromes
we
stand
to
gain
tremendous
insight
into
obesogenic
pathways
.
In
this
review
we
focus
particularly
on
Bardet-
Biedl
syndrome
,
whose
molecular
genetics
and
cell
biology
has
been
elucidated
recently
,
and
Prader-
Willi
syndrome
,
the
commonest
obesity
syndrome
due
to
loss
of
imprinted
genes
on
15
q
11
-
13
.
We
also
discuss
highlights
of
other
genetic
obesity
syndromes
including
Alstrom
syndrome
,
Cohen
syndrome
,
Albright
's
hereditary
osteodystrophy
(
pseudohypoparathyroidism
)
,
Carpenter
syndrome
,
MOMO
syndrome
,
Rubinstein-
Taybi
syndrome
,
cases
with
deletions
of
6
q
16
,
1
p
36
,
2
q
37
and
9
q
34
,
maternal
uniparental
disomy
of
chromosome
14
,
fragile
X
syndrome
and
Börjeson-
Forssman-
Lehman
syndrome
.
Diseases
Validation
Diseases presenting
"multi-system genetic disorders"
symptom
cohen syndrome
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