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Macular fibrosis in Coats disease.
[coats disease]
The
purpose
of
this
study
was
to
describe
the
angiographic
features
and
visual
impact
of
macular
fibrosis
in
patients
with
Coats
disease
.
This
is
a
single
institution
retrospective
case
series
.
Charts
of
patients
diagnosed
with
Coats
disease
between
1973
and
2007
were
reviewed
.
Data
collected
included
patient
demographics
,
treatment
method
,
initial
and
final
logarithm
of
the
minimum
angle
of
resolution
visual
acuity
,
photographic
findings
,
angiographic
characteristics
,
and
anatomical
outcome
.
Forty
-
seven
patients
were
identified
with
adequate
imaging
and
posttreatment
follow-up
.
Average
age
at
presentation
was
38
years
(
4
-
82
years
)
.
Average
follow-up
was
4
.
9
years
(
0
-
17
years
)
.
Macular
fibrosis
was
identified
in
11
patients
(
23
%
)
.
At
presentation
,
the
average
logarithm
of
the
minimum
angle
of
resolution
visual
acuity
was
as
follows
:
all
patients
,
0
.
67
;
patients
with
macular
fibrosis
,
1
.
14
;
and
patients
without
macular
fibrosis
,
0
.
50
(
P
=
0
.
01
,
2
-
tailed
Student
's
t-test
)
.
The
average
posttreatment
logarithm
of
the
minimum
angle
of
resolution
visual
acuity
was
as
follows
:
all
patients
,
0
.
78
;
patients
with
macular
fibrosis
,
0
.
97
;
and
patients
without
macular
fibrosis
,
0
.
70
(
P
=
0
.
26
)
.
Macular
fibrosis
was
associated
with
a
pigmented
spot
at
the
point
of
apparent
intraretinal
vascular
anastamosis
.
Fluorescein
angiography
showed
leakage
consistent
with
neovascularization
that
appeared
to
be
intraretinal
.
Macular
fibrosis
is
a
common
finding
in
Coats
disease
,
occurring
in
23
%
of
our
patients
.
It
may
be
a
result
of
intraretinal
neovascularization
and
is
associated
with
a
worse
vision
outcome
.
Diseases
Validation
Diseases presenting
"a worse vision outcome"
symptom
coats disease
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