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Macular fibrosis in Coats disease.
[coats disease]
The
purpose
of
this
study
was
to
describe
the
angiographic
features
and
visual
impact
of
macular
fibrosis
in
patients
with
Coats
disease
.
This
is
a
single
institution
retrospective
case
series
.
Charts
of
patients
diagnosed
with
Coats
disease
between
1973
and
2007
were
reviewed
.
Data
collected
included
patient
demographics
,
treatment
method
,
initial
and
final
logarithm
of
the
minimum
angle
of
resolution
visual
acuity
,
photographic
findings
,
angiographic
characteristics
,
and
anatomical
outcome
.
Forty
-
seven
patients
were
identified
with
adequate
imaging
and
posttreatment
follow-up
.
Average
age
at
presentation
was
38
years
(
4
-
82
years
)
.
Average
follow-up
was
4
.
9
years
(
0
-
17
years
)
.
Macular
fibrosis
was
identified
in
11
patients
(
23
%
)
.
At
presentation
,
the
average
logarithm
of
the
minimum
angle
of
resolution
visual
acuity
was
as
follows
:
all
patients
,
0
.
67
;
patients
with
macular
fibrosis
,
1
.
14
;
and
patients
without
macular
fibrosis
,
0
.
50
(
P
=
0
.
01
,
2
-
tailed
Student
's
t-test
)
.
The
average
posttreatment
logarithm
of
the
minimum
angle
of
resolution
visual
acuity
was
as
follows
:
all
patients
,
0
.
78
;
patients
with
macular
fibrosis
,
0
.
97
;
and
patients
without
macular
fibrosis
,
0
.
70
(
P
=
0
.
26
)
.
Macular
fibrosis
was
associated
with
a
pigmented
spot
at
the
point
of
apparent
intraretinal
vascular
anastamosis
.
Fluorescein
angiography
showed
leakage
consistent
with
neovascularization
that
appeared
to
be
intraretinal
.
Macular
fibrosis
is
a
common
finding
in
Coats
disease
,
occurring
in
23
%
of
our
patients
.
It
may
be
a
result
of
intraretinal
neovascularization
and
is
associated
with
a
worse
vision
outcome
.
Diseases
Validation
Diseases presenting
"common finding"
symptom
adrenal incidentaloma
coats disease
cohen syndrome
cushing syndrome
dentinogenesis imperfecta
dystrophic epidermolysis bullosa
familial mediterranean fever
inclusion body myositis
systemic capillary leak syndrome
waldenström macroglobulinemia
zellweger syndrome
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