Rare Diseases Symptoms Automatic Extraction
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Peripheral retinal nonperfusion in fellow eyes in coats disease.
[coats disease]
To
measure
peripheral
nonperfusion
and
describe
bilateral
vascular
abnormalities
in
patients
with
Coats
disease
,
emphasizing
subtle
findings
in
the
contralateral
eyes
of
patients
diagnosed
with
unilateral
disease
.
Clinical
records
,
including
retina
drawings
and
fluorescein
angiography
images
obtained
under
anesthesia
,
were
retrospectively
reviewed
from
consecutive
pediatric
patients
with
Coats
disease
.
The
main
outcome
measure
was
disk
diameters
of
peripheral
nonperfusion
and
proportion
of
Coats
disease
patients
with
bilateral
findings
.
Twenty
-
two
of
32
patients
with
Coats
disease
had
bilateral
abnormal
peripheral
vasculature
.
In
Group
1
(
classic
Coats
disease
:
presumed
unilateral
,
ocular
only
disease
)
,
15
of
24
patients
had
peripheral
nonperfusion
>
2
disk
diameters
in
their
contralateral
eyes
,
5
with
telangiectasis
and
/
or
microaneurysms
.
Seven
of
8
patients
in
Group
2
(
Coats-like
disease
:
systemic
and
/
or
clinically
bilateral
disease
)
had
bilateral
vascular
anomalies
.
Bilateral
vascular
abnormalities
are
more
common
in
Coats
disease
than
previously
reported
.
This
observation
supports
a
systemic
and
/
or
genetic
association
with
Coats
disease
.
Patients
with
Coats
disease
should
have
careful
evaluation
of
the
periphery
of
the
less
affected
eye
,
preferably
with
fluorescein
angiography
,
to
identify
vascular
changes
not
visible
clinically
.
Both
eyes
warrant
surveillance
over
the
lifetime
of
the
patient
for
potential
progression
to
exudative
disease
that
would
warrant
treatment
.
Diseases
Validation
Diseases presenting
"only disease"
symptom
coats disease
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