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Information processing deficits in children with early and continuously treated phenylketonuria?
[classical phenylketonuria]
Thirty
-
three
patients
with
early
and
continuously
treated
classical
phenylketonuria
(
PKU
)
and
33
controls
matched
for
age
,
gender
,
and
educational
level
of
both
parents
,
participated
in
a
chronometric
study
exploring
elementary
mechanisms
of
information
processing
.
Subjects
performed
speeded
performance
tasks
designed
to
systematically
vary
the
load
on
perceptual
,
central
,
and
output-related
mechanisms
of
information
processing
.
A
preliminary
analysis
of
the
data
indicated
that
the
overall
performance
of
patients
with
early
and
continuously
treated
PKU
practically
matched
that
of
the
controls
on
all
three
tasks
.
Although
this
finding
must
be
interpreted
with
caution
as
it
is
based
on
only
a
preliminary
analysis
of
the
data
,
it
suggests
that
PKU
patients
who
are
continuously
maintained
on
a
well-controlled
phenylalanine-
restricted
diet
are
not
deficient
in
the
elementary
mechanisms
of
processing
.
Given
the
more
recent
findings
indicating
that
young
children
with
early
-treated
classical
PKU
have
specific
cognitive
deficits
in
the
executive
function
skills
,
despite
relatively
strict
dietary
control
,
the
authors
suggest
that
future
studies
should
focus
on
these
higher-order
cognitive
processes
.
