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A random Abstract
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Neurological findings in early treated phenylketonuria.
[classical phenylketonuria]
Twenty
early
treated
,
normal
intelligent
patients
(
IQ
:
mean
101
.
4
,
SD
10
.
0
;
age
:
mean
10
.
11
,
SD
1
.
3
years
)
with
classical
phenylketonuria
and
20
age-
,
sex-
and
IQ-matched
healthy
controls
were
investigated
for
neurological
outcome
,
especially
with
regard
to
fine
motor
ability
using
the
motor
performance
task
(
"
Motorische
Leistungsserie
"
)
.
No
pathological
findings
were
seen
on
clinical
neurological
examination
.
The
patient
group
had
significantly
poorer
results
in
a
concentration
task
(
Test-d-
2
)
as
well
as
in
some
subtests
of
the
motor
performance
task
.
Patients
had
difficulties
in
tasks
which
needed
speed
and
precision
of
arm-
hand
-
finger
movements
.
High
serum
phenylalanine
concentrations
were
significantly
correlated
with
these
deficiencies
in
fine
motor
ability
.
Our
data
demonstrated
mild
neurological
impairment
even
in
early
and
relatively
strictly
treated
patients
with
phenylketonuria
.
Diseases
Validation
Diseases presenting
"difficulties in tasks"
symptom
classical phenylketonuria
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