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Executive function in treated phenylketonuria as measured by the one-back and two-back versions of the continuous performance test.
[classical phenylketonuria]
The
executive
dysfunction
hypothesis
in
treated
phenylketonuria
was
investigated
by
means
of
the
one
-back
and
two
-back
versions
of
the
continuous
performance
test
.
Eleven
non-
retarded
,
primary
school
-age
children
with
classical
phenylketonuria
who
had
been
treated
early
and
continuously
were
indistinguishable
from
healthy
,
matched
controls
on
the
measures
and
test
performance
was
not
predicted
by
historical
or
concurrent
plasma
phenylalanine
concentrations
.
Mean
lifetime
phenylalanine
concentrations
for
the
phenylketonuric
subjects
were
within
ranges
currently
recommended
as
dietary
optima
in
the
United
Kingdom
.
The
negative
neuropsychological
test
findings
add
weight
to
the
rationale
for
this
policy
.
Diseases
Validation
Diseases presenting
"matched controls on the measures and test performance"
symptom
classical phenylketonuria
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