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Effects of L-phenylalanine on acetylcholinesterase and Na+,K+-ATPase activities in suckling rat frontal cortex, hippocampus and hypothalamus.
[classical phenylketonuria]
The
effect
of
different
L-
phenylalanine
(
Phe
)
concentrations
(
0
.
12
-
12
.
1
mM
)
on
acetylcholinesterase
(
AChE
)
,
(
Na
+
,
K
+
)
-
ATPase
and
Mg
2
+
-
ATPase
activities
was
evaluated
in
homogenates
of
suckling
rat
frontal
cortex
,
hippocampus
and
hypothalamus
.
Phe
,
at
high
concentrations
,
reduced
AChE
activity
in
frontal
cortex
and
hippocampus
by
18
%
-
20
%
.
On
the
contrary
,
the
enzyme
activity
was
unaltered
in
the
hypothalamus
.
Na
+
,
K
+
-
ATPase
was
stimulated
by
high
levels
of
the
amino
acid
,
both
in
the
frontal
cortex
and
the
hypothalamus
by
60
%
,
whereas
it
was
inhibited
in
the
hippocampus
by
40
%
.
Mg
2
+
-
ATPase
was
not
influenced
by
Phe
.
It
is
suggested
that
:
a
)
In
the
frontal
cortex
,
the
improper
acetylcholine
(
ACh
)
release
,
due
to
AChE
inhibition
by
Phe
,
combined
with
the
stimulation
of
Na
+
,
K
+
-
ATPase
,
possibly
explain
tremor
and
the
hyperkinetic
behaviour
in
patients
with
classical
phenylketonuria
(
PKU
)
.
b
)
In
the
hippocampus
,
inhibition
of
AChE
by
Phe
could
lead
to
problems
in
memory
,
while
Na
+
,
K
+
-
ATPase
inhibition
by
Phe
may
induce
metabolic
disorders
and
electrical
instability
of
the
synaptosomal
membrane
.
c
)
In
the
hypothalamus
,
the
behavioral
problems
in
PKU
"
off
diet
"
may
be
related
to
noradrenaline
(
NA
)
levels
,
which
are
probably
correlated
with
the
modulated
Na
+
,
K
+
-
ATPase
by
Phe
.
Diseases
Validation
Diseases presenting
"high concentrations"
symptom
classical phenylketonuria
congenital adrenal hyperplasia
erdheim-chester disease
erythropoietic protoporphyria
familial hypocalciuric hypercalcemia
homocystinuria without methylmalonic aciduria
phenylketonuria
primary hyperoxaluria type 1
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